February 05, 2021

NRG Oncology Trial Results Show Safety of Adaptive Radiotherapy in Non-Small Cell Lung Cancer Patients, Open Paths to Future Prospective Studies

The NRG Oncology and the American College of Radiology Network (ACRIN) multicenter, phase II trial, NRG-RTOG 1106/ACRIN 6697 is the first randomized trial to demonstrate the feasibility and safety of performing adaptive radiotherapy escalation in patients with locally advanced non-small cell lung cancer (NSCLC). The improvement of in-field tumor control appeared similar to the level (1% improvement with 1Gy dose escalation) of the Single Institutional Study of adaptive radiotherapy performed at University of Michigan, and different from that of RTOG617 with non-adaptive high dose radiation in stage III NSCLC. The results were presented at the virtual edition of the International Association for the Study of Lung Cancer 2020 World Conference on Lung Cancer, Singapore.

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